du 24 juin 2021 au 25 juin 2021
Publié le 17 juin 2021 Mis à jour le 17 juin 2021

Séminaire de Igor Aronson

Séminaire
Séminaire

Phase-field approach to cell migration on 3D asymmetric substrates

Jeudi 24 juin, 14h00 (en distanciel sur Microsoft Teams) ( Team CY Warwick Theoretical Physics )

Phase-field approach to cell migration on 3D asymmetric substrates

Igor ARONSON
(Dept. of Material Science and Engineering, Penn State University, PA, USA)

Cell migration often occurs in an asymmetric three-dimensional environment. External constraints on cell motility play significant roles in many vital processes, e.g., during development, differentiation, the immune response, and live-threatening pathologies like cancer metastasis. We have developed a physics-driven three-dimensional computational modeling framework that describes the lamellipodium-based motion of cells in arbitrarily shaped and topographically structured surroundings [1,2]. We use it to investigate primary in vitro model system scenarios: vertical confinement, confinement in microchannels, motion on fibers, and imposed modulations of surface topography. We found that confinement, substrate curvature, and topography can change the direction of migration along axes defined by the constraints. We also investigated cell guidance on nanostructured substrates represented by asymmetric sawteeth. Our model serves as a benchmark to systematically explore lamellipodium-based motility and its interaction with the environment.

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